After finishing runner-up in the 2007 Red Bull MotoGP Rookies Cup, in 2008 he won the Italian 125GP championship and the European 125cc Championship and he debuted in the 125cc World Championship; he raced in the latter class for the following two seasons before switching, in 2011, to the FIM Superstock 1000 Cup, where he was champion in 2015. This season Lorenzo will be riding for Milwaukee Aprilia on the Aprilia RSV4 RF.